Skin Substitutes

Advanced Skin Substitutes for Modern Wound Care

Explore a powerful portfolio of regenerative grafts and wound coverings designed to accelerate healing and restore skin integrity.

🌿 Featured Products

At M2Clinic360, we connect clinics with high-performance skin substitutes and grafts that go beyond standard dressings. From amniotic membranes to collagen-based scaffolds, our curated lineup supports conservative therapy and advanced wound healing protocols.

Whether you're dealing with diabetic ulcers, burns, or surgical wounds, these products are engineered to optimize healing outcomes with minimal complications.

🌿 Amniotic-Based Products

🧬 Collagen & ECM-Based Wraps

💧Hydrated/

Hydrogel Variants

🛡️ Hybrid or Multi-layered Options

🌿 Amniotic-Based Skin Substitute

✅ BioVance

🧬 Type:

Dehydrated Human Amniotic Membrane Allograft

✨ What Is It?

BioVance is a sterile, single-layer amniotic graft designed to enhance wound healing by delivering natural extracellular matrix components without triggering an immune response.

🩹 What It’s Used For?

~ Diabetic foot ulcers
~ Venous leg ulcers
~ Pressure injuries

💡 Why Clinics Love It:

~ No prep required—ready to use
~ Conforms easily to wound beds
~ Long shelf life and consistent quality

📦 How It Works:

BioVance delivers growth factors and structural proteins that promote epithelial cell migration and tissue remodeling while minimizing inflammation.

📊 Clinical Backing:

Proven in outpatient and hospital wound settings with high success rates for chronic and non-healing wounds.

✅ Membrane Wrap

🧬 Type:

Dehydrated Amniotic Membrane Allograft

✨ What Is It?

Membrane Wrap is a flexible amniotic graft designed for straightforward wound coverage, offering protective barrier properties while releasing anti-inflammatory healing signals.

🩹 What It’s Used For?

~ Surgical incisions
~ Traumatic wounds
~ Chronic ulcers

💡 Why Clinics Love It:

~ Simple and fast to apply
~ Conforms to wound contours
~ Minimal inflammatory response

📦 How It Works:

Rehydrates on contact and binds to the wound surface, releasing key growth factors while forming a natural shield that supports regeneration.

📊 Clinical Backing:

Frequently used in surgical repair protocols for its ease of use and reliable outcomes in skin closure.

✅ Derm-Maxx

🧬 Type:

Dehydrated Amniotic Membrane Allograft

✨ What Is It?

Derm-Maxx is a premium amniotic wound covering crafted to preserve natural tissue structure and maximize regenerative healing. It’s ideal for conservative therapy and outpatient wound care.

🩹 What It’s Used For?

~ Chronic wounds
~ Surgical wounds
~ Pressure ulcers

💡 Why Clinics Love It:

~ High strength for easier handling
~ Supports natural tissue recovery
~ No refrigeration required

📦 How It Works:

Delivers anti-inflammatory cytokines and growth factors directly to the wound, helping modulate pain and accelerate healing.

📊 Clinical Backing:

Trusted in wound care clinics for its durability, easy application, and ability to speed up closure in complex wounds.

✅ Amnio-Maxx

🧬 Type:

Dual-Layer Amniotic Membrane Allograft

✨ What Is It?

Amnio-Maxx is a biologic patch composed of two stacked amniotic layers, offering double the growth factor content to maximize healing potential in surgical and chronic wounds.

🩹 What It’s Used For?

~ Surgical incisions
~ Inflammatory wound sites
~ Scar tissue prevention

💡 Why Clinics Love It:

~ Dual-layer for enhanced durability and bioactivity
~ Can be placed in any direction—no orientation needed
~ Excellent tensile strength for robotic/laparoscopic use

📦 How It Works:

Provides a structural and bioactive environment that supports cell migration and tissue regeneration while minimizing adhesion and scar formation.

📊 Clinical Backing:

Frequently used in operating rooms and wound centers for its anti-inflammatory, anti-scarring, and regenerative capabilities.

✅ AmnioAMP-MP

🧬 Type:

Micronized Amniotic Particulate (Injectable Allograft)

✨ What Is It?

AmnioAMP-MP is a micronized particulate derived from amniotic tissue, optimized for injection into soft tissues and joint spaces to promote healing and reduce inflammation.

🩹 What It’s Used For?

~ Tendon and ligament injuries
~ Joint inflammation
~ Soft tissue regeneration

💡 Why Clinics Love It:

~ Injectable format—minimally invasive
~ High concentration of growth factors
~ Versatile across multiple specialties

📦 How It Works:

Once injected, the micronized particles release anti-inflammatory proteins and regenerative signals to support local tissue repair and reduce pain.

📊 Clinical Backing:

Widely used in regenerative orthopedics and pain management for post-operative recovery and non-surgical alternatives.

✅ XCell Amnio

🧬 Type:

Cryopreserved Amniotic Membrane Allograft

✨ What Is It?

XCell Amnio is a cryopreserved, viable amniotic membrane designed to maintain the biological activity of native tissue while offering protective wound coverage and accelerated healing.

🩹 What It’s Used For?

~ Burn sites
~ Chronic ulcers
~ Surgical recovery

💡 Why Clinics Love It:

~ Preserves full bioactive profile
~ Ready to use after thawing
~ Supports revascularization and epithelial closure

📦 How It Works:

Retains live cellular elements and proteins that activate upon placement, jumpstarting the body’s healing response.

📊 Clinical Backing:

Validated in peer-reviewed studies for its effectiveness in both acute and chronic wound environments.

✅ Acesso DL

🧬 Type:

Dual-Layer Amniotic Membrane Allograft

✨ What Is It?

Acesso DL is a dehydrated dual-layer amniotic graft designed for enhanced surgical handling, with robust mechanical strength and regenerative properties for complex wound healing.

🩹 What It’s Used For?

~ Soft tissue surgical repair
~ Nerve and tendon protection
~ Chronic non-healing wounds

💡 Why Clinics Love It:

~ Strong yet flexible for deep wound coverage
~ Dual-layer boosts healing potential
~ Can be placed without concern for orientation

📦 How It Works:

Provides a natural matrix of growth factors and anti-inflammatory proteins while shielding the wound from external contaminants.

📊 Clinical Backing:

Preferred in surgical specialties for its durability and consistent clinical outcomes in wound regeneration.

✅ Acesso TL

🧬 Type:

Micronized Amniotic Particulate (Injectable Allograft)

✨ What Is It?

AmnioAMP-MP is a micronized particulate derived from amniotic tissue, optimized for injection into soft tissues and joint spaces to promote healing and reduce inflammation.

🩹 What It’s Used For?

~ Tendon and ligament injuries
~ Joint inflammation
~ Soft tissue regeneration

💡 Why Clinics Love It:

~ Injectable format—minimally invasive
~ High concentration of growth factors
~ Versatile across multiple specialties

📦 How It Works:

Once injected, the micronized particles release anti-inflammatory proteins and regenerative signals to support local tissue repair and reduce pain.

📊 Clinical Backing:

Widely used in regenerative orthopedics and pain management for post-operative recovery and non-surgical alternatives.

✅ XCell Amnio

🧬 Type:

Flowable Amniotic Matrix

✨ What Is It?

DermaBind FM is a flowable form of amniotic tissue designed for injectable delivery into complex wound tunnels, undermining, and irregularly shaped defects.

🩹 What It’s Used For?

~ Tunneling wounds
~ Deep ulcers
~ Surgical defects with irregular depth

💡 Why Clinics Love It:

~ Injects easily into hard-to-reach areas
~ Delivers growth factors deep into wound pockets
~ Reduces risk of infection in closed spaces

📦 How It Works:

The flowable matrix fills tissue voids and delivers regenerative components throughout the wound environment to promote inside-out healing.

📊 Clinical Backing:

Ideal for complex wound scenarios and backed by use in both outpatient and surgical settings.

✅ AmchoPlast

🧬 Type:

Dehydrated Amniotic Membrane Allograft

✨ What Is It?

AmchoPlast is a sterile amniotic graft engineered for advanced wound care. It delivers natural healing factors and a protective barrier in a durable, easy-to-handle format ideal for outpatient and surgical applications.

🩹 What It’s Used For?

~ Diabetic ulcers
~ Surgical wounds
~ Tendon and nerve coverage

💡 Why Clinics Love It:

~ Excellent tensile strength
~ Fast rehydration
~ Flexible and trim-friendly for complex sites

📦 How It Works:

AmchoPlast activates upon hydration, delivering regenerative proteins and reducing inflammation at the wound site while protecting tissue from external stress.

📊 Clinical Backing:

Used across multispecialty clinics for its ability to promote granulation, reduce scar tissue, and integrate seamlessly with native tissue.

🧬 Collagen & ECM-Based Wraps

✅ Esano ACA

🧬 Type:

Acellular Collagen Allograft

✨ What Is It?

Esano ACA is a sterile, acellular dermal matrix made from human collagen. It’s processed to remove all cellular components while preserving the natural extracellular structure needed to support tissue regeneration.

🩹 What It’s Used For?

~ Full-thickness wounds
~ Surgical grafting
~ Complex wound closures

💡 Why Clinics Love It:

~ Human-derived—high compatibility
~ No risk of cellular rejection
~ Strong, pliable, and easy to shape

📦 How It Works:

When applied to the wound, Esano ACA acts as a scaffold that encourages native cell migration, angiogenesis, and new collagen formation.

📊 Clinical Backing:

Supported by surgical case studies and wound center outcomes demonstrating improved tissue regeneration and reduced healing times.

💧 Hydrated/Hydrogel Variants

✅ NeoStim TL

🧬 Type:

Hydrated Amniotic Tissue – Triple-Layer

✨ What Is It?

NeoStim TL is a thick, triple-layered hydrated amniotic graft developed for wounds requiring extended protection and healing power. Its design offers a sustained release of growth factors for advanced tissue recovery.

🩹 What It’s Used For?

~ Deep or exudating wounds
~ Pressure injuries
~ Complex surgical sites

💡 Why Clinics Love It:

~ Triple-layer for long-lasting moisture and structure
~ Flexible yet strong
~ Great for high-friction areas or long-term coverage

📦 How It Works:

The hydrated triple layers slowly release natural cytokines and proteins while shielding the wound from desiccation and external stress.

📊 Clinical Backing:

Trusted in hospital and post-acute care settings for complex wound management and moisture retention.

✅ NeoStim

🧬 Type:

Hydrated Amniotic Tissue – Single Layer

✨ What Is It?

NeoStim is a single-layer hydrated amniotic graft ideal for wounds needing moisture balance and enhanced healing without the bulk of a thicker matrix.

🩹 What It’s Used For?

~ Chronic ulcers
~ Surgical wound beds
~ Skin tears and abrasions

💡 Why Clinics Love It:

~ Easy to apply and conform
~ Maintains wound hydration
~ Speeds re-epithelialization

📦 How It Works:

Delivers anti-inflammatory and regenerative components while maintaining a moist wound environment that supports healthy tissue regrowth.

📊 Clinical Backing:

Used widely in outpatient wound clinics for quick application and predictable healing support.

✅ NeoStim DL

🧬 Type:

Hydrated Amniotic Tissue – Dual-Layer

✨ What Is It?

NeoStim DL is a dual-layer version of the NeoStim graft, offering a thicker, more durable matrix that enhances bioactivity and coverage for moderate to complex wounds.

🩹 What It’s Used For?

~ Surgical wounds
~ Burn sites
~ Ulcers with moderate depth

💡 Why Clinics Love It:

~ Extra structure without sacrificing flexibility
~ Moisture-retentive and protective
~ Delivers longer-lasting regenerative impact

📦 How It Works:

The dual-layer design traps moisture and provides a scaffold for cellular infiltration, triggering faster wound remodeling.

📊 Clinical Backing:

Backed by clinicians for its performance in hard-to-heal and slow-progressing wounds.

✅ Membrane Wrap Hydro

🧬 Type:

Hydrated Amniotic Membrane with Hydrogel Technology

✨ What Is It?

Membrane Wrap Hydro is an enhanced amniotic graft that combines the regenerative benefits of amniotic tissue with hydrogel moisture retention, making it ideal for sensitive or painful wound sites.

🩹 What It’s Used For?

~ Burn wounds
~ Radiation dermatitis
~ Skin graft donor sites
~ Painful or dry chronic wounds

💡 Why Clinics Love It:

~ Soothing moisture layer reduces pain
~ Easy to apply to fragile skin
~ Prevents wound dehydration and sticking

📦 How It Works:

The hydrogel-infused amniotic layer delivers healing proteins while maintaining optimal hydration, creating a protected, low-friction environment for epithelial repair.

📊 Clinical Backing:

Preferred in dermatology and burn care settings for its fast application, pain relief, and superior healing outcomes in delicate tissue areas.

🛡️ Hybrid or Multi-Layered Options

Amniotic-Based or Hybrid Substitute (pending manufacturer specs)

Amniotic + Collagen Hybrid (likely composite)

✅ SimpliMax

🧬 Type:

Amniotic + Collagen Composite Graft

✨ What Is It?

SimpliMax is a hybrid skin substitute combining amniotic membrane with a collagen-rich matrix for a dual-action healing experience—moisture retention and structural support in one product.

🩹 What It’s Used For?

~ Non-healing ulcers
~ Post-op wound beds
~ High-tension surgical closures

💡 Why Clinics Love It:

~ Combines the best of both healing worlds
~ Strong yet soft—great for contoured areas
~ Promotes full-thickness skin repair

📦 How It Works:

The amniotic layer releases growth factors while the collagen matrix serves as a scaffold for cell infiltration, angiogenesis, and regeneration.

📊 Clinical Backing:

Used across wound care centers for stubborn wounds that need both hydration and structure to heal.

✅ Membrane Wrap TriLayer

🧬 Type:

Triple-Layer Amniotic Allograft

✨ What Is It?

Membrane Wrap TriLayer features three stacked amniotic membranes for maximum protection, durability, and extended healing—especially effective in large or deep wound beds.

🩹 What It’s Used For?

~ Deep diabetic ulcers
~ Pressure wounds
~ High-friction areas

💡 Why Clinics Love It:

~ Triple protection—superior coverage
~ Great for high-risk patients
~ Longer shelf life and wound retention

📦 How It Works:

Each layer works in synergy to release growth factors over time while maintaining a moist, immune-privileged environment that resists infection and promotes cell growth.

📊 Clinical Backing:

Clinically used in advanced wound centers for wounds that require durable coverage and staged healing support.

✅ Cocoon

🧬 Type:

Multi-Layered Biologic Scaffold (Hybrid Composition)

✨ What Is It?

Cocoon is a biologically active, multi-layered wound covering designed for maximum flexibility, strength, and healing power. Engineered for wounds needing both protection and dynamic regeneration.

🩹 What It’s Used For?

~ Tunneling wounds
~ Post-surgical sites
~ Limb preservation therapy

💡 Why Clinics Love It:

~ Flexible like skin, strong like scaffold
~ Easy to place in hard-to-dress areas
~ Sustained healing action over time

📦 How It Works:

Layers of biologic material form a composite barrier that adapts to wound topography, releasing healing proteins and shielding tissue from shear forces.

📊 Clinical Backing:

Applied in limb salvage programs and surgical wound care where strength, healing speed, and adaptability are critical.

🔬 Conservative Therapy First:
The Power of Collagen Prep

🧠 Collegen Is The Prerequisite For Skin Subs Wound Care

Before grafts, before advanced wound care…
collagen gets the skin ready to heal.

For many patients, the healing journey starts with something simple — daily collagen therapy.

Applied directly to the wound, this powdered or gel-based treatment helps stimulate natural repair and prepares the site for more advanced care like skin substitutes or grafts.


At M2Clinic360, we don’t just drop products on your desk — we help you build effective wound care protocols.

Conservative therapy is often the key to qualifying patients for biologic treatment and ensuring the best clinical outcomes.

Advanced Skin Healing Starts Here — Discover Our Top-Rated Skin Subs

We assist with DME coverage, patient education, and billing compliance—

so you can deliver care without the guesswork.

➡️ Stay tuned for our upcoming DME Collagen Protocol Page —

or book a call today to get early access to our guide.

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